Article
Aging results in accumulation of M1 and M2 hepatic macrophages and a differential response to gadolinium chloride.
Histochemistry and cell biology - 1 Jan 2020
Bloomer Steven A, Moyer Eric D, Brown Kyle E, Kregel Kevin C
Abstract excerpt
Macrophages have vital roles in innate immunity by modulating the inflammatory response via their ability to alter their phenotype from pro-inflammatory (M1) to anti-inflammatory (M2). Aging increases activation of the innate immune system, and macrophage numbers increase in the aged liver. Since macrophages also produce free radical molecules, they are a potential source of age-related oxidative injury in the...
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