Article
Phenotype Determines Nanoparticle Uptake by Human Macrophages from Liver and Blood.
ACS nano - 28 Mar 2017
MacParland Sonya A, Tsoi Kim M, Ouyang Ben, Ma Xue-Zhong, Manuel Justin, Fawaz Ali, Ostrowski Mario A, Alman Benjamin A, Zilman Anton, Chan Warren C W, McGilvray Ian D
Abstract excerpt
A significant challenge to delivering therapeutic doses of nanoparticles to targeted disease sites is the fact that most nanoparticles become trapped in the liver. Liver-resident macrophages, or Kupffer cells, are key cells in the hepatic sequestration of nanoparticles. However, the precise role that the macrophage phenotype plays in nanoparticle uptake is unknown. Here, we show that the human macrophage...
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