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Article

Aging influences the cardiac macrophage phenotype and function during steady state and during inflammation.

Aging cell - 1 Aug 2021

Esfahani Noushin Saljoughian, Wu Qian, Kumar Naresh, Ganesan Latha Prabha, Lafuse William P, Rajaram Murugesan V S

Abstract excerpt

Aging-mediated immune dysregulation affects the normal cardiac immune cell phenotypes and functions, resulting in cardiac distress. During cardiac inflammation, immune activation is critical for mounting the regenerative responses to maintain normal heart function. We investigated the impact of aging on myeloid cell phenotype and function during cardiac inflammation induced by a sub-lethal dose of LPS. Our data...

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PMID: 34342127
DOI: 10.1111/acel.13438
PMCID: PMC8373275

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