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Article

Hepatic macrophage accumulation with aging: cause for concern?

American journal of physiology. Gastrointestinal and liver physiology - 1 Apr 2021

Bloomer Steven A, Moyer Eric D

Abstract excerpt

Aging is associated with chronic, low-grade inflammation that adversely affects physiological function. The liver regulates systemic inflammation; it is a source of cytokine production and also scavenges bacteria from the portal circulation to prevent infection of other organs. The cells with primary roles in these functions, hepatic macrophages, become more numerous in the liver with "normal" aging (i.e., in the...

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PMID: 33470190
DOI: 10.1152/ajpgi.00286.2020

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