Article
Compound prioritization methods increase rates of chemical probe discovery in model organisms.
Chemistry & biology - 28 Oct 2011
Wallace Iain M, Urbanus Malene L, Luciani Genna M, Burns Andrew R, Han Mitchell K L, Wang Hao, Arora Kriti, Heisler Lawrence E, Proctor Michael, St Onge Robert P, Roemer Terry, Roy Peter J, Cummins Carolyn L, Bader Gary D, Nislow Corey, Giaever Guri
Abstract excerpt
Preselection of compounds that are more likely to induce a phenotype can increase the efficiency and reduce the costs for model organism screening. To identify such molecules, we screened ~81,000 compounds in Saccharomyces cerevisiae and identified ~7500 that inhibit cell growth. Screening these growth-inhibitory molecules across a diverse panel of model organisms resulted in an increased phenotypic hit-rate....
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