Article
A regression model approach to enable cell morphology correction in high-throughput flow cytometry.
Molecular systems biology - 27 Sept 2011
Knijnenburg Theo A, Roda Oriol, Wan Yakun, Nolan Garry P, Aitchison John D, Shmulevich Ilya
Abstract excerpt
Cells exposed to stimuli exhibit a wide range of responses ensuring phenotypic variability across the population. Such single cell behavior is often examined by flow cytometry; however, gating procedures typically employed to select a small subpopulation of cells with similar morphological characteristics make it difficult, even impossible, to quantitatively compare cells across a large variety of experimental...
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