Article
Predictive evolution of metabolic phenotypes using model-designed environments.
Molecular systems biology - 1 Oct 2022
Jouhten Paula, Konstantinidis Dimitrios, Pereira Filipa, Andrejev Sergej, Grkovska Kristina, Castillo Sandra, Ghiachi Payam, Beltran Gemma, Almaas Eivind, Mas Albert, Warringer Jonas, Gonzalez Ramon, Morales Pilar, Patil Kiran R
Abstract excerpt
Adaptive evolution under controlled laboratory conditions has been highly effective in selecting organisms with beneficial phenotypes such as stress tolerance. The evolution route is particularly attractive when the organisms are either difficult to engineer or the genetic basis of the phenotype is complex. However, many desired traits, like metabolite secretion, have been inaccessible to adaptive selection due...
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