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Article

ABCC2 c.-24 C>T single-nucleotide polymorphism was associated with the pharmacokinetic variability of deferasirox in Chinese subjects.

European journal of clinical pharmacology - 1 Jan 2020

Cao Kangna, Ren Guanghui, Lu Chengcan, Wang Yao, Tan Yanan, Zhou Jing, Zhang Yongjie, Lu Yang, Li Ning, Chen Xijing, Zhao Di

Abstract excerpt

PURPOSE: Our aim was to evaluate the influence of genetic polymorphisms involved in the metabolism and transportation of deferasirox on deferasirox pharmacokinetics in the Chinese population. METHODS: Thirty-eight healthy Chinese subjects were administered with a single dose of 20 mg kg-1 deferasirox. Allelic discriminations for eight single-nucleotide polymorphisms (SNPs) in UDP-glucuronosyltransferase 1A1, 1A3...

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Identifiers

PMID: 31677118
DOI: 10.1007/s00228-019-02775-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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