Article
Effect of Genetic Polymorphisms on the Pharmacokinetics of Deferasirox in Healthy Chinese Subjects and an Artificial Neural Networks Model for Pharmacokinetic Prediction.
European journal of drug metabolism and pharmacokinetics - 1 Dec 2020
Chen Jinliang, Xu Yichao, Lou Honggang, Jiang Bo, Shao Rong, Yang Dandan, Hu Yin, Ruan Zourong
Abstract excerpt
BACKGROUND AND OBJECTIVE: Deferasirox is an oral iron chelator used to reduce iron levels in iron-overloaded patients with transfusion-dependent anemia or non-transfusion-dependent thalassemia. This study investigated the effects of genetic polymorphisms on the pharmacokinetics of deferasirox in healthy Chinese subjects and constructed a pharmacokinetic prediction model based on physiologic factors and genetic...
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