Article
Role of pharmacogenetics on deferasirox AUC and efficacy.
Pharmacogenomics - 1 Apr 2016
Cusato Jessica, Allegra Sarah, De Francia Silvia, Massano Davide, Piga Antonio, D'Avolio Antonio
Abstract excerpt
AIM: We evaluated deferasirox pharmacokinetic according to SNPs in genes involved in its metabolism and elimination. Moreover, we defined a plasma area under the curve cut-off value predicting therapy response. PATIENTS & METHODS: Allelic discrimination was performed by real-time PCR. Drug plasma concentrations were measured by a high performance liquid chromatography system coupled with an ultraviolet method....
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