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Article

Pharmacogenomic and Clinical Predictors of Deferasirox Response in Transfusion-Dependent Thalassemia Identified Using Whole-Genome Sequencing.

Clinical and translational science - 1 Dec 2025

Yampayon Kittika, Sakares Watchara, Pitinanon Krittin, Limwongse Chanin, Srichairatanakool Somdet, Koonyosying Pimpisid, Sukasem Chonlaphat, Triparn Kwankom, Piriyapongsa Jittima, Ekwattanakit Supachai, Viprakasit Vip, Yodsurang Varalee

Abstract excerpt

Deferasirox is a widely used oral iron chelator in patients with transfusion-dependent thalassemia, but considerable variability in treatment response remains a clinical challenge. This study applied whole-genome sequencing to investigate genetic predictors of deferasirox response in 88 Thai patients. This approach enabled comprehensive detection of both known and novel variants across eight key genes involved in...

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Share to Blood Transfusion
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Multidrug Resistance-Associated Protein 2

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Source

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Identifiers

PMID: 41414879
DOI: 10.1111/cts.70441
PMCID: PMC12715416

Genes

MAF
ABCC2
UGT1A3
TG
UGT1A1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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Pharmacogenomic and Clinical Predictors of Deferasirox Response in Transfusion-Dependent Thalassemia Identified Using Whole-Genome Sequencing.PMID 41414879Read ↗

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