Mice expressing the variant rs1143679 allele of ITGAM (CD11b) show impaired DC-mediated T cell proliferation.

doi:10.1007/s00335-019-09819-y

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Article

Mice expressing the variant rs1143679 allele of ITGAM (CD11b) show impaired DC-mediated T cell proliferation.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Oct 2019

Avery Justin T, Jimenez Rachel V, Blake Joseph L, Wright Tyler T, Leόn-Ruiz Beatriz, Schoeb Trenton R, Szalai Alexander J, Bullard Daniel C

Abstract excerpt

Genome-wide association studies (GWAS) and functional genomic analyses have implicated several ITGAM (CD11b) single-nucleotide polymorphisms (SNPs) in the development of SLE and other disorders. ITGAM encodes the αM chain of the β2 integrin Mac-1, a receptor that plays important roles in myeloid cell functions. The ITGAM SNP rs1143679, which results in an arginine to histidine change at amino acid position 77 of...

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PMID: 31673770
DOI: 10.1007/s00335-019-09819-y
PMCID: PMC6842653

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