Article
Multiple lupus-associated ITGAM variants alter Mac-1 functions on neutrophils.
Arthritis and rheumatism - 1 Nov 2013
Zhou Yebin, Wu Jianming, Kucik Dennis F, White Nathan B, Redden David T, Szalai Alexander J, Bullard Daniel C, Edberg Jeffrey C
Abstract excerpt
OBJECTIVE: Multiple studies have demonstrated that single-nucleotide polymorphisms (SNPs) in the ITGAM locus (including the nonsynonymous SNPs rs1143679, rs1143678, and rs1143683) are associated with systemic lupus erythematosus (SLE). ITGAM encodes the protein CD11b, a subunit of the β2 integrin...
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