Article
CD11b activation suppresses TLR-dependent inflammation and autoimmunity in systemic lupus erythematosus.
The Journal of clinical investigation - 3 Apr 2017
Faridi Mohd Hafeez, Khan Samia Q, Zhao Wenpu, Lee Ha Won, Altintas Mehmet M, Zhang Kun, Kumar Vinay, Armstrong Andrew R, Carmona-Rivera Carmelo, Dorschner Jessica M, Schnaith Abigail M, Li Xiaobo, Ghodke-Puranik Yogita, Moore Erica, Purmalek Monica, Irizarry-Caro Jorge, Zhang Tingting, Day Rachael, Stoub Darren, Hoffmann Victoria, Khaliqdina Shehryar Jehangir, Bhargava Prachal, Santander Ana M, Torroella-Kouri Marta, Issac Biju, Cimbaluk David J, Zloza Andrew, Prabhakar Rajeev, Deep Shashank, Jolly Meenakshi, Koh Kwi Hye, Reichner Jonathan S, Bradshaw Elizabeth M, Chen JianFeng, Moita Luis F, Yuen Peter S, Li Tsai Wanxia, Singh Bhupinder, Reiser Jochen, Nath Swapan K, Niewold Timothy B, Vazquez-Padron Roberto I, Kaplan Mariana J, Gupta Vineet
Abstract excerpt
Genetic variations in the ITGAM gene (encoding CD11b) strongly associate with risk for systemic lupus erythematosus (SLE). Here we have shown that 3 nonsynonymous ITGAM variants that produce defective CD11b associate with elevated levels of type I interferon (IFN-I) in lupus, suggesting a direct link between reduced CD11b activity and the chronically increased inflammatory status in patients. Treatment with the...
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