CD11b suppresses TLR7-driven inflammatory signaling to protect against lupus nephritis

Abstract excerpt

Lupus Nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE) that affects kidney function. Here, we investigated the role of CD11b, a protein encoded by the ITGAM gene, in the development of LN and its functional activation as a therapeutic strategy. Genetic coding variants of ITGAM significantly increase the risk for SLE and LN by producing a less active CD11b and leading to elevated leve...

Topics

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• CD11b Antigen
• Forkhead Box Protein O3
• Interferon Regulatory Factor-3
• Interferon Type I
• Lupus Erythematosus, Systemic
• Mice, Inbred MRL lpr
• Proto-Oncogene Proteins c-akt
• Toll-Like Receptors

Identifiers and source

Literature Corpus work

dd307b78-48fd-51ee-9907-f61dfc38f359

DOI

10.1101/2024.07.26.605143