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Article

The variant of CD11b, rs1143679 within ITGAM, is associated with systemic lupus erythematosus and clinical manifestations in Brazilian patients.

Human immunology - 1 Feb 2014

Toller-Kawahisa Juliana Escher, Vigato-Ferreira Isabel Cristina Costa, Pancoto João Alexandre Trés, Mendes-Junior Celso Teixeira, Martinez Edson Zangiacomi, Palomino Gustavo Martelli, Louzada-Júnior Paulo, Donadi Eduardo Antônio, Del Lama José Eduardo Cavalcanti, Marzocchi-Machado Cleni Mara

Abstract excerpt

BACKGROUND/AIMS: Immune responses mediated by complement receptors (CR) are impaired in patients with systemic lupus erythematosus (SLE). Regarding CR3 (CD11b/CD18), the CD11b subunit is encoded by the ITGAM gene and a single nucleotide polymorphism (G230A; rs1143679) in ITGAM changes an arginine to a histidine at position 77 (R77H). We assessed whether the variant R77H, rs1143679 within ITGAM, is associated with...

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Topics

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Share to Antibodies, Antiphospholipid
Share to Antibody Formation
Share to Brazil
Share to CD11b Antigen
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Share to Genetic Association Studies
Share to Lupus Erythematosus, Systemic
Share to Nephritis

Source

Identifiers

PMID: 24269694
DOI: 10.1016/j.humimm.2013.11.013

Genes

ITGAM

Variants

rs1143679
rs1143679

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The variant of CD11b, rs1143679 within ITGAM, is associated with systemic lupus erythematosus and clinical manifestations in Brazilian patients.PMID 24269694Read ↗

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