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Article

The many faces of Mac-1 in autoimmune disease.

Immunological reviews - 1 Jan 2016

Rosetti Florencia, Mayadas Tanya N

Abstract excerpt

Mac-1 (CD11b/CD18) is a β2 integrin classically regarded as a pro-inflammatory molecule because of its ability to promote phagocyte cytotoxic functions and enhance the function of several effector molecules such as FcγR, uPAR, and CD14. Nevertheless, recent reports have revealed that Mac-1 also plays significant immunoregulatory roles, and genetic variants in ITGAM, the gene that encodes CD11b, confer risk for...

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Share to CD11b Antigen
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Lupus Erythematosus, Systemic

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Source

Identifiers

PMID: 26683153
DOI: 10.1111/imr.12373

Genes

ITGAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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