Article

Differences in expression of tumor suppressor, innate immune, inflammasome, and potassium/gap junction channel host genes significantly predict viral reservoir size during treated HIV infection

2023-01-11

Abstract excerpt

The major barrier to an HIV cure is the persistence of infected cells that evade host immune surveillance despite effective antiretroviral therapy (ART). Most prior host genetic HIV studies have focused on identifying DNA polymorphisms (e.g., CCR5Δ32 , MHC class I alleles) associated with viral load among untreated “elite controllers” (~1% of HIV+ individuals who are able to control virus without ART). However, t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1217ceea-bd8c-54ee-95c9-3d88f328160a
DOI: 10.1101/2023.01.10.523535

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Differences in expression of tumor suppressor, innate immune, inflammasome, and potassium/gap junction channel host genes significantly predict viral reservoir size during treated HIV infectionDOI 10.1101/2023.01.10.523535Read

Host variation in type I interferon signaling genes (MX1), C-C chemokine receptor type 5 gene, and major histocompatibility complex class I alleles in treated HIV+ noncontrollers predict viral reservoir size.Semantic proximity Read

Identification of distinct HIV reservoir phenotypes and associated immune landscapes.Semantic proximity Read

Plasma Virome of HIV-infected Subjects on Suppressive Antiretroviral Therapy Reveals Association of Differentially Abundant Viruses with Distinct T-cell Phenotypes and InflammationSemantic proximity Read

The latent HIV reservoir: current advances in genetic sequencing approachesSemantic proximity Read

Multi-Omics Clustering Differentiates the Total and Intact HIV Reservoirs and Related Host Immune MechanismsSemantic proximity Read

Transcriptionally Active HIV Reservoirs Enriched for Interferon-Inducible APOBEC3-Related Mutational Signatures Associate with Arterial InflammationSemantic proximity Read

Genetic and molecular landscape of comorbidities in people living with HIVSemantic proximity Read

Reservoir and Phylogenetic Signatures Identify Distinct Subsets of HIV-1 Nonsuppressible ViremiaSemantic proximity Read

Omic Technologies in HIV: Searching Transcriptional Signatures Involved in Long-Term Non-Progressor and HIV Controller Phenotypes.Semantic proximity Read

Soluble immune checkpoints as correlates for HIV persistence and T cell function in people with HIV on antiretroviral therapySemantic proximity Read

Host genetic and immune factors drive evasion of HIV-1 pathogenesis in viremic non-progressors.Semantic proximity Read

Killer immunoglobulin-like receptor (KIR) genes are associated with the risk of episodes of high-level and detectable viremia among HIV controllersSemantic proximity Read