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Article

Genotype-Fitness Maps of EGFR-Mutant Lung Adenocarcinoma Chart the Evolutionary Landscape of Resistance for Combination Therapy Optimization.

Cell systems - 22 Jan 2020

Bolan Patrick O, Zviran Asaf, Brenan Lisa, Schiffman Joshua S, Dusaj Neville, Goodale Amy, Piccioni Federica, Johannessen Cory M, Landau Dan A

Abstract excerpt

Cancer evolution poses a central obstacle to cure, as resistant clones expand under therapeutic selection pressures. Genome sequencing of relapsed disease can nominate genomic alterations conferring resistance but sample collection lags behind, limiting therapeutic innovation. Genome-wide screens offer a complementary approach to chart the compendium of escape genotypes, anticipating clinical resistance. We...

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Identifiers

PMID: 31668800
DOI: 10.1016/j.cels.2019.10.002
PMCID: PMC6981068

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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