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Article

Quantitative In Vivo Analyses Reveal a Complex Pharmacogenomic Landscape in Lung Adenocarcinoma.

Cancer research - 1 Sept 2021

Li Chuan, Lin Wen-Yang, Rizvi Hira, Cai Hongchen, McFarland Christopher D, Rogers Zoe N, Yousefi Maryam, Winters Ian P, Rudin Charles M, Petrov Dmitri A, Winslow Monte M

Abstract excerpt

The lack of knowledge about the relationship between tumor genotypes and therapeutic responses remains one of the most critical gaps in enabling the effective use of cancer therapies. Here, we couple a multiplexed and quantitative experimental platform with robust statistical methods to enable pharmacogenomic mapping of lung cancer treatment responses in vivo. The complex map of genotype-specific treatment...

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Source

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Identifiers

PMID: 34215621
DOI: 10.1158/0008-5472.CAN-21-0716
PMCID: PMC8416777

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