Article

Programmed evolution: Using asexual gene drives to sculpt tumor populations and combat genetic diversity

2023-08-29

Abstract excerpt

<title>Abstract</title> <p>Resistance evolution is responsible for the failure of most targeted anticancer therapies. Tumor heterogeneity is so profound that pre-existing resistance is thought to be guaranteed at the time that advanced disease is detected. The practice of waiting for treatment failure and then responding to the refractory tumor with next-generation targeted therapies locks clinicians in an evolut...

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Literature Corpus work: 9aefc11b-ed9e-511a-81a1-6d631d740677
DOI: 10.21203/rs.3.rs-3002621/v1

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