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Article

Characterizing Evolutionary Dynamics Reveals Strategies to Exhaust the Spectrum of Subclonal Resistance in EGFR-Mutant Lung Cancer.

Cancer research - 1 Aug 2023

Müller Nina, Lorenz Carina, Ostendorp Jenny, Heisel Felix S, Friese Ulrich P, Cartolano Maria, Plenker Dennis, Tumbrink Hannah, Heimsoeth Alena, Baedeker Philipp, Weiss Jonathan, Ortiz-Cuaran Sandra, Büttner Reinhard, Peifer Martin, Thomas Roman K, Sos Martin L, Berg Johannes, Brägelmann Johannes

Abstract excerpt

The emergence of resistance to targeted therapies restrains their efficacy. The development of rationally guided drug combinations could overcome this currently insurmountable clinical challenge. However, our limited understanding of the trajectories that drive the outgrowth of resistant clones in cancer cell populations precludes design of drug combinations to forestall resistance. Here, we propose an iterative...

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Share to Drug Resistance, Neoplasm
Share to Carcinoma, Non-Small-Cell Lung

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 37289018
DOI: 10.1158/0008-5472.CAN-22-2605

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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