Article

Defining the Sensitivity Landscape of 74,389 EGFR Variants to Tyrosine Kinase Inhibitors

2021-09-01

Abstract excerpt

<h4>Background: </h4> Tyrosine kinase inhibitors (TKIs) therapy is a standard treatment for patients with advanced non-small-cell lung carcinoma (NSCLC) when activating epidermal growth factor receptor ( EGFR ) mutations are detected. However, except for the well-studied EGFR mutations, most EGFR mutations lack treatment regimens. <h4>Methods: </h4>: We constructed two EGFR variant libraries containing substitutio...

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Literature Corpus work: d26e4ec5-ac0e-52d1-bd43-581475a8207d
DOI: 10.21203/rs.3.rs-847350/v1

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