Article
Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling.
Proceedings of the National Academy of Sciences of the United States of America - 11 Dec 2007
McDermott Ultan, Sharma Sreenath V, Dowell Lori, Greninger Patricia, Montagut Clara, Lamb Jennifer, Archibald Heidi, Raudales Raul, Tam Angela, Lee Diana, Rothenberg S Michael, Supko Jeffrey G, Sordella Raffaella, Ulkus Lindsey E, Iafrate A John, Maheswaran Shyamala, Njauw Ching Ni, Tsao Hensin, Drew Lisa, Hanke Jeff H, Ma Xiao-Jun, Erlander Mark G, Gray Nathanael S, Haber Daniel A, Settleman Jeffrey
Abstract excerpt
Kinase inhibitors constitute an important new class of cancer drugs, whose selective efficacy is largely determined by underlying tumor cell genetics. We established a high-throughput platform to profile 500 cell lines derived from diverse epithelial cancers for sensitivity to 14 kinase inhibitors. Most inhibitors were ineffective against unselected cell lines but exhibited dramatic cell killing of small...
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