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Article

Optogenetic inhibition of Delta reveals digital Notch signalling output during tissue differentiation.

EMBO reports - 5 Dec 2019

Viswanathan Ranjith, Necakov Aleksandar, Trylinski Mateusz, Harish Rohit Krishnan, Krueger Daniel, Esposito Emilia, Schweisguth Francois, Neveu Pierre, De Renzis Stefano

Abstract excerpt

Spatio-temporal regulation of signalling pathways plays a key role in generating diverse responses during the development of multicellular organisms. The role of signal dynamics in transferring signalling information in vivo is incompletely understood. Here, we employ genome engineering in Drosophila melanogaster to generate a functional optogenetic allele of the Notch ligand Delta (opto-Delta), which replaces...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31668010
DOI: 10.15252/embr.201947999
PMCID: PMC6893285

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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