Notch activity in neural cells triggered by a mutant allele with altered glycosylation.

Abstract excerpt

The receptor protein Notch is inactive in neural precursor cells despite neighboring cells expressing ligands. We investigated specification of the R8 neural photoreceptor cells that initiate differentiation of each Drosophila ommatidium. The ligand Delta was required in R8 cells themselves, consistent with a lateral inhibitor function for Delta. By contrast, Delta expressed in cells adjacent to R8 could not...

Topics

• Animals
• Cell Line
• Drosophila Proteins
• Drosophila melanogaster
• Fucose
• Glycosylation
• Intracellular Signaling Peptides and Proteins