Article

Optogenetic Rescue Reveals Spatiotemporal Rules of Germ-Layer Patterning

2025-12-11

Abstract excerpt

Embryonic cells must interpret morphogen signals that vary in both time and space, but the rules by which they decode these dynamics remain unclear. Here we combine optogenetics with human 2D gastruloids to define minimal WNT signaling rules for germ-layer patterning. We block endogenous WNT secretion to create a “blank canvas” and reconstitute signaling using light-gated LRP6. Systematic temporal scans reveal a n...

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Identifiers and source

Literature Corpus work: 945ef7cd-1cc0-56ae-adac-1e3191a61aca
DOI: 10.64898/2025.12.08.693069

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