Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MMAR_2770, a new enzyme involved in biotin biosynthesis, is essential for the growth of Mycobacterium marinum in macrophages and zebrafish.

Microbes and infection - 1 Jan 2011

Yu Jia, Niu Chen, Wang Decheng, Li Ming, Teo Woeishyang, Sun Gang, Wang Jianping, Liu Jun, Gao Qian

Abstract excerpt

Biotin, which functions as an essential cofactor for certain carboxylases and decarboxylases, is synthesized by a multistep pathway in microorganisms and plants. Biotin biosynthesis has not been studied in detail in mycobacteria. In this study, we isolated a mutant of Mycobacterium marinum in whi...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Proteins
Share to Biotin
Share to Cell Line

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Macrophages

Share to Mutation

Share to Mycobacterium Infections, Nontuberculous

Share to Zebrafish

Source

Identifiers

PMID: 20974274
DOI: 10.1016/j.micinf.2010.08.010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20974274-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MMAR_2770, a new enzyme involved in biotin biosynthesis, is essential for the growth of Mycobacterium marinum in macrophages and zebrafish.PMID 20974274Read ↗

Validating Conditionally Essential Targets: Discovery of the First Orally Effective Biotin Inhibitor against <i>Mycobacterium Tuberculosis</i>Semantic proximity Read ↗

Genetic and chemical control of tuberculostearic acid production in Mycobacterium avium subspecies paratuberculosis.Semantic proximity Read ↗

AccD6, a Key Carboxyltransferase Essential for Mycolic Acid Synthesis in Mycobacterium tuberculosis, Is Dispensable in a Nonpathogenic StrainSemantic proximity Read ↗

Down-regulation of malate synthase in Mycobacterium tuberculosis H37Ra leads to reduced stress tolerance, persistence and survival in macrophages.Semantic proximity Read ↗

Mycothione reductase as a potential target in the fight against Mycobacterium abscessus infectionsSemantic proximity Read ↗

A vitamin B₁₂ transporter in Mycobacterium tuberculosis.Semantic proximity Read ↗

Evaluating the sensitivity of Mycobacterium tuberculosis to biotin deprivation using regulated gene expression.Semantic proximity Read ↗

Uncovering the Roles of <i>Mycobacterium tuberculosis melH</i> in Redox and Bioenergetic Homeostasis: Implications for Antitubercular TherapySemantic proximity Read ↗

Mimicking the human environment in mice reveals that inhibiting biotin biosynthesis is effective against antibiotic-resistant pathogens.Semantic proximity Read ↗

Cell envelope remodeling requires high concentrations of biotin during <i>Mycobacterium abscessus</i> model lung infectionSemantic proximity Read ↗

<i>De novo</i> cobalamin biosynthesis, transport and assimilation and cobalamin-mediated regulation of methionine biosynthesis in <i>Mycobacterium smegmatis</i>Semantic proximity Read ↗

Essential roles of methionine and <i>S</i> -adenosylmethionine in the autarkic lifestyle of <i>Mycobacterium tuberculosis</i>Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.