Article
Biotin Deficiency Induces Intestinal Dysbiosis Associated with an Inflammatory Bowel Disease-like Phenotype.
Nutrients - 4 Jan 2023
Yang Julianne C, Jacobs Jonathan P, Hwang Michael, Sabui Subrata, Liang Fengting, Said Hamid M, Skupsky Jonathan
Abstract excerpt
Biotin is an essential vitamin and critical cofactor in several metabolic pathways, and its deficiency has been linked to several disorders including inflammatory bowel disease (IBD). We previously reported that biotin deficiency (BD) in mice, whether modeled through intestine-specific deletion of biotin transporter (SMVT-icKO) or through a biotin-deficient diet, resulted in intestinal inflammation consistent...
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