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A folate inhibitor exploits metabolic differences in Pseudomonas aeruginosa for narrow-spectrum targeting

9 Apr 2024

Abstract excerpt

Pseudomonas aeruginosa is a leading cause of hospital-acquired infections for which the development of antibiotics is urgently needed. Unlike most enteric bacteria, P. aeruginosa lacks enzymes required to scavenge exogenous thymine. An appealing strategy to selectively target P. aeruginosa is to disrupt thymidine synthesis while providing exogenous thymine. However, known antibiotics that perturb thymidine...

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PMID: 38594311
DOI: 10.1038/s41564-024-01665-2

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