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Article

Direct Measurement of Cardiac Na+ Channel Conformations Reveals Molecular Pathologies of Inherited Mutations.

Circulation. Arrhythmia and electrophysiology - 1 Oct 2015

Varga Zoltan, Zhu Wandi, Schubert Angela R, Pardieck Jennifer L, Krumholz Arie, Hsu Eric J, Zaydman Mark A, Cui Jianmin, Silva Jonathan R

Abstract excerpt

BACKGROUND: Dysregulation of voltage-gated cardiac Na(+) channels (NaV1.5) by inherited mutations, disease-linked remodeling, and drugs causes arrhythmias. The molecular mechanisms whereby the NaV1.5 voltage-sensing domains (VSDs) are perturbed to pathologically or therapeutically modulate Na(+) current (INa) have not been specified. Our aim was to correlate INa kinetics with conformational changes within the 4...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26283144
DOI: 10.1161/CIRCEP.115.003155
PMCID: PMC4618166

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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