Article
Arg753Gln Polymorphisms in the Toll-Like Receptor 2 Gene are Associated with Cytomegalovirus Infection in Egyptian Bone Marrow Recipients.
Endocrine, metabolic & immune disorders drug targets - 1 Jan 2020
El-Nabi Sobhy Hassab, Sayed Samia, Abd-Elhafez Mohamed A, Elfiky Mohamed, Abdel Moneim Ahmed E, El-Garawani Islam
Abstract excerpt
BACKGROUND: Previous studies have shown that cytomegalovirus (CMV) induced innate immune response via activation of Toll-like receptor 2 (TLR2). The association between CMV among specific single-nucleotide polymorphisms (SNPs) in the TLR2 gene was also investigated. OBJECTIVE: This study investigated the relationship between specific SNPs in the TLR2 gene (G>A), TLR2-Arg753Gln (rs5743708), and CMV replication...
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