Article
Influence of single-nucleotide polymorphisms in TLR3 (rs3775291) and TLR9 (rs352139) on the risk of CMV infection in kidney transplant recipients.
Frontiers in immunology - 1 Jan 2022
Redondo Natalia, Rodríguez-Goncer Isabel, Parra Patricia, Ruiz-Merlo Tamara, López-Medrano Francisco, González Esther, Polanco Natalia, Trujillo Hernando, Hernández Ana, San Juan Rafael, Andrés Amado, Aguado José María, Fernández-Ruiz Mario
Abstract excerpt
Risk stratification for cytomegalovirus (CMV) infection after kidney transplantation (KT) remains to be determined. Since endosomal toll-like receptors (TLRs) are involved in viral sensing, we investigated the impact of common single-nucleotide polymorphisms (SNPs) located within TLR3 and TLR9 genes on the occurrence of overall and high-level (≥1,000 IU/ml) CMV infection in a cohort of 197 KT recipients....
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