Toll-like receptor 1 variation increases the risk of transplant-related mortality in hematologic malignancies.

doi:10.1016/j.trim.2016.06.002

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Article

Toll-like receptor 1 variation increases the risk of transplant-related mortality in hematologic malignancies.

Transplant immunology - 1 Sept 2016

Uchino Kaori, Mizuno Shohei, Mizutani Motonori, Horio Tomohiro, Hanamura Ichiro, Espinoza J Luis, Matsuo Keitaro, Onizuka Makoto, Kashiwase Koichi, Morishima Yasuo, Fukuda Takahiro, Kodera Yoshihisa, Doki Noriko, Miyamura Koichi, Mori Takehiko Mori Takehiko, Takami Akiyoshi

Abstract excerpt

Toll-like receptor 1 (TLR1) genetic variant (rs5743551, -7202A>G) has been reported to be associated with susceptibility to various infectious diseases. We retrospectively examined the impact of TLR1 variation on transplant outcomes in a cohort of 320 patients who underwent unrelated HLA-matched bone marrow transplantation (BMT) for hematologic malignancies. A multivariate analysis showed that the G/G genotype in...

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PMID: 27369862
DOI: 10.1016/j.trim.2016.06.002

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TLR1

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