Activating mutations and translocations in the guanine exchange factor VAV1 in peripheral T-cell lymphomas.

doi:10.1073/pnas.1608839114

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Article

Activating mutations and translocations in the guanine exchange factor VAV1 in peripheral T-cell lymphomas.

Proceedings of the National Academy of Sciences of the United States of America - 24 Jan 2017

Abate Francesco, da Silva-Almeida Ana C, Zairis Sakellarios, Robles-Valero Javier, Couronne Lucile, Khiabanian Hossein, Quinn S Aidan, Kim Mi-Yeon, Laginestra Maria Antonella, Kim Christine, Fiore Danilo, Bhagat Govind, Piris Miguel Angel, Campo Elias, Lossos Izidore S, Bernard Olivier A, Inghirami Giorgio, Pileri Stefano, Bustelo Xosé R, Rabadan Raul, Ferrando Adolfo A, Palomero Teresa

Abstract excerpt

Peripheral T-cell lymphomas (PTCLs) are a heterogeneous group of non-Hodgkin lymphomas frequently associated with poor prognosis and for which genetic mechanisms of transformation remain incompletely understood. Using RNA sequencing and targeted sequencing, here we identify a recurrent in-frame deletion (VAV1 Δ778-786) generated by a focal deletion-driven alternative splicing mechanism as well as novel VAV1 gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28062691
DOI: 10.1073/pnas.1608839114
PMCID: PMC5278460

Genes

VAV1
THAP4

Provenance

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