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Article

Overexpression of MIG-6 in the cartilage induces an osteoarthritis-like phenotype in mice.

Arthritis research & therapy - 19 May 2020

Bellini Melina, Pest Michael A, Miranda-Rodrigues Manuela, Qin Ling, Jeong Jae-Wook, Beier Frank

Abstract excerpt

BACKGROUND: Osteoarthritis (OA) is the most common form of arthritis and characterized by degeneration of the articular cartilage. Mitogen-inducible gene 6 (Mig-6) has been identified as a negative regulator of the epidermal growth factor receptor (EGFR). Cartilage-specific Mig-6 knockout (KO) mice display increased EGFR signaling, an anabolic buildup of the articular cartilage, and formation of chondro-osseous...

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Identifiers

PMID: 32430054
DOI: 10.1186/s13075-020-02213-z
PMCID: PMC7236969

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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