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Article

Targeted disruption of Mig-6 in the mouse genome leads to early onset degenerative joint disease.

Proceedings of the National Academy of Sciences of the United States of America - 16 Aug 2005

Zhang Yu-Wen, Su Yanli, Lanning Nathan, Swiatek Pamela J, Bronson Roderick T, Sigler Robert, Martin Richard W, Vande Woude George F

Abstract excerpt

Degenerative joint disease, also known as osteoarthritis, is the most common joint disorder in human beings. The molecular mechanism underlying this disease is not fully understood. Here, we report that disruption of mitogen-inducible gene 6 (Mig-6) in mice by homologous recombination leads to early onset degenerative joint disease, which is revealed by simultaneous enlargement and deformity of multiple joints,...

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Identifiers

PMID: 16087873
DOI: 10.1073/pnas.0505171102
PMCID: PMC1187996

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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