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Genetic and reproductive strategies to prevent mitochondrial diseases

3 Mar 2025

Abstract excerpt

Mitochondrial DNA (mtDNA) diseases pose unique challenges for genetic counselling and require tailored approaches to address recurrence risks and reproductive options. The intricate dynamics of mtDNA segregation and heteroplasmy shift significantly impact the chances of having affected children. In addition to natural pregnancy, oocyte donation, and adoption, IVF-based approaches can reduce the risk of disease...

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PMID: 40085924
DOI: 10.1093/humupd/dmaf004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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