Back to search

Article

Reproductive Medicine Involving Mitochondrial DNA Modification: Evolution, Legality, and Ethics

2018-08-16

Abstract excerpt

Human oocytes have an abundance of mitochondria that have their own genome. Mitochondrial functions are exerted through evolutionarily-developed interactions between the nucleus and mitochondria. Since 1996, fertility clinics have practiced various types of germline mitochondrial DNA (mtDNA) modification that alter the composition of mtDNA copies in oocytes or zygotes using micromanipulation. Experimental reproduc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
f3aa2e99-b249-57ec-a48f-e4f565978410
DOI
10.33590/emjreprohealth/10311157
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Reproductive Medicine Involving Mitochondrial DNA Modification: Evolution, Legality, and EthicsDOI 10.33590/emjreprohealth/10311157
Genetic and reproductive strategies to prevent mitochondrial diseasesSemantic proximity
Novel reproductive technologies to prevent mitochondrial disease.Semantic proximity
Mitochondrial replacement therapy and assisted reproductive technology: A paradigm shift toward treatment of genetic diseases in gametes or in early embryosSemantic proximity
Clinical and ethical implications of mitochondrial gene transfer.Semantic proximity
Reproductive options in mitochondrial disease.Semantic proximity
Mitochondrial Modification Techniques and Ethical IssuesSemantic proximity
Mitochondrial replacement by genome transfer in human oocytes: Efficacy, concerns, and legalitySemantic proximity
The Role of Mitochondria in Human Fertility and Early Embryo Development: What Can We Learn for Clinical Application of Assessing and Improving Mitochondrial DNA?Semantic proximity
Mitochondrial DNA disorders: from pathogenic variants to preventing transmission.Semantic proximity
Epigenetic and experimental modifications in early mammalian development: Part I: Mitochondria: potential roles in embryogenesis and nucleocytoplasmic transferSemantic proximity
Ooplasmic transfer in human oocytes: efficacy and concerns in assisted reproductionSemantic proximity
Mitochondria and Their Role in Human ReproductionSemantic proximity
Select a neighboring publication to make it the new centre.