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Article

Nuclear genome transfer in human oocytes eliminates mitochondrial DNA variants.

Nature - 31 Jan 2013

Paull Daniel, Emmanuele Valentina, Weiss Keren A, Treff Nathan, Stewart Latoya, Hua Haiqing, Zimmer Matthew, Kahler David J, Goland Robin S, Noggle Scott A, Prosser Robert, Hirano Michio, Sauer Mark V, Egli Dieter

Abstract excerpt

Mitochondrial DNA mutations transmitted maternally within the oocyte cytoplasm often cause life-threatening disorders. Here we explore the use of nuclear genome transfer between unfertilized oocytes of two donors to prevent the transmission of mitochondrial mutations. Nuclear genome transfer did not reduce developmental efficiency to the blastocyst stage, and genome integrity was maintained provided that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23254936
DOI: 10.1038/nature11800
PMCID: PMC7924261

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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