Article
Multi-ancestry genome-wide association and integrated multi-omics analyses of endometriosis and its clinical manifestations.
Nature genetics - 1 May 2026
Koller Dora, He Jun, Løkhammer Solveig, Aranda Selena, Qiu Dan, Davtian David, Chen Qianyu, Xu Ziang, Mao Zhongzheng, Friligkou Eleni, Karaca Sefayet, Cormand Bru, Flores Idhaliz, Altmäe Signe, Mitjans Marina, Cabrera-Mendoza Brenda, Polimanti Renato
Abstract excerpt
Endometriosis is a chronic systemic disease affecting ~10% of women, yet its genetic basis and molecular mechanisms remain poorly understood. Hence, here we conducted a genome-wide association study of endometriosis and adenomyosis in ~1.4 million women, including 105,869 cases, aiming to expand loci discovery across ancestries, dissect symptom-specific effects and integrate multi-omic data. We identified 80...
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