Article

Expanding the genetic landscape of endometriosis: Integrative -omics analyses implicate key genes and pathways in a multi-ancestry study of over one million women

2025-12-04

Abstract excerpt

<title>Abstract</title> <p>We report the findings of a genome-wide association study (GWAS) meta-analysis of endometriosis across 14 biobanks worldwide, including 32% non-European patient participants, as part of the Global Biobank Meta-Analysis Initiative (GBMI). Out of 58 total loci (29 previously unreported), the largest meta-analysis accounted for 46 (20 previously unreported). We detected the first gen...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8b8e45e3-52bc-5026-8292-9b5ecc7d3f75
DOI: 10.21203/rs.3.rs-8116602/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Expanding the genetic landscape of endometriosis: Integrative -omics analyses implicate key genes and pathways in a multi-ancestry study of over one million womenDOI 10.21203/rs.3.rs-8116602/v1Read

Expanding the genetic landscape of endometriosis: Integrative -omics analyses implicate key genes and pathways in a multi-ancestry study of over one million womenSemantic proximity Read

Multi-ancestry genome-wide association study of endometriosis and its clinical manifestations in ~1.4 million women: translating gene discovery into pathogenic mechanisms and therapeutic targetsSemantic proximity Read

Large-scale genome-wide association meta-analysis of endometriosis reveals 13 novel loci and genetically-associated comorbidity with other pain conditionsSemantic proximity Read

Multi-ancestry genome-wide association and integrated multi-omics analyses of endometriosis and its clinical manifestations.Semantic proximity Read

New Insights into Genetics of Endometriosis—A Comprehensive Literature ReviewSemantic proximity Read

Identification and Reproducibility of Novel Combinatorial Genetic Risk Factors for Endometriosis across UK and US Patient CohortsSemantic proximity Read

Enhancing Genetic Association Power in Endometriosis through Unsupervised Clustering of Clinical Subtypes Identified from Electronic Health RecordsSemantic proximity Read

Enhancing genetic association power in endometriosis through unsupervised clustering of clinical subtypes identified from electronic health recordsSemantic proximity Read

Genetic variants underlying risk of endometriosis: insights from meta-analysis of eight genome-wide association and replication datasets.Semantic proximity Read

A multi-level investigation of the genetic relationship between endometriosis and ovarian cancer histotypesSemantic proximity Read

The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions.Semantic proximity Read

Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis.Semantic proximity Read