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Article

A genome-to-proteome map reveals how natural variants drive proteome diversity and shape fitness.

Science (New York, N.Y.) - 9 Oct 2025

Jakobson Christopher M, Hartl Johannes, Trébulle Pauline, Mülleder Michael, Jarosz Daniel F, Ralser Markus

Abstract excerpt

Understanding how genetic variation translates into complex phenotypes remains a fundamental challenge. In this work, we address this by mapping genome-to-proteome relationships in 800 progeny of a cross between two yeast strains adapted to distinct environments. Despite the modest genetic distance between the parents, we observed notable proteomic diversity and mapped more than 6400 genotype-protein...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41066569
DOI: 10.1126/science.adu3198
PMCID: PMC12989164

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