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Serum HDL-cholesterol is associated with the clinical-biological profile of early-stage Parkinson's disease patients independently of APOE.

Neurobiology of aging - 1 Nov 2025

Mascioli Davide, Conti Matteo, Bissacco Jacopo, Bovenzi Roberta, Simonetta Clara, Buttarazzi Veronica, Mancini Maria, Bagetta Silvio, Sancesario Giulia Maria, Maftei Daniela, Veltri Federica, Marchionni Enrica, Stefani Alessandro, Mercuri Nicola Biagio, Pieri Massimo, Schirinzi Tommaso

Abstract excerpt

Emerging evidence highlights a possible interplay between serum lipid profiles and Parkinson's disease (PD), but the biological underpinnings remain largely unexplored. In this cross-sectional study, we investigated whether serum lipid levels (total cholesterol, high-density lipoprotein cholesterol (HDL), non-high-density lipoprotein cholesterol, and triglycerides) were associated with clinical severity and...

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Identifiers

PMID: 40633495
DOI: 10.1016/j.neurobiolaging.2025.07.004

Genes

APOE

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