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Article

The Role of Piezo 1 in the Study of Intervertebral Disc Degeneration: Phenotype, Mechanism and Treatment.

Orthopaedic surgery - 1 May 2026

Li Guangye, Feng Chaoqun, Huang Haoyun, Deng Junwen, Yang Fei, Chen Rigao

Abstract excerpt

BACKGROUND: Intervertebral disc degeneration (IVDD), a prevalent spinal disorder, is closely associated with abnormal mechanical stress. The nucleus pulposus (NP), annulus fibrosus (AF), and cartilaginous endplate (CEP) collectively respond to mechanical loading. The mechanosensitive Piezo 1 ion channel senses mechanical stress changes and converts the mechanical signals into chemical signals, and serves a...

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Share to Endoplasmic Reticulum Chaperone BiP
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41942106
DOI: 10.1111/os.70291
PMCID: PMC13139052

Genes

NLRP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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