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Article

A Tympanic Piezo-Bioreactor Modulates Ion Channel-Associated Mechanosignaling to Stabilize Phenotype and Promote Tenogenesis in Human Tendon-Derived Cells.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Dec 2024

Fernandez-Yague Marc A, Palma Matteo, Tofail Syed A M, Duffy Maeve, Quinlan Leo R, Dalby Mathew J, Pandit Abhay, Biggs Manus J

Abstract excerpt

Preserving the function of human tendon-derived cells (hTDCs) during cell expansion is a significant challenge in regenerative medicine. In this study, a non-genetic approach is introduced to control the differentiation of hTDCs using a newly developed tympanic bioreactor. The system mimics the functionality of the human tympanic membrane, employing a piezoelectrically tuned acoustic diaphragm made of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39439240
DOI: 10.1002/advs.202405711
PMCID: PMC11615817

Genes

PIEZO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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