Article
The loop of phenotype: Dynamic reciprocity links tenocyte morphology to tendon tissue homeostasis.
Acta biomaterialia - 1 Jun 2023
Dede Eren Aysegul, Vermeulen Steven, Schmitz Tara C, Foolen Jasper, de Boer Jan
Abstract excerpt
Cells and their surrounding extracellular matrix (ECM) are engaged in dynamic reciprocity to maintain tissue homeostasis: cells deposit ECM, which in turn presents the signals that define cell identity. This loop of phenotype is obvious for biochemical signals, such as collagens, which are produced by and presented to cells, but the role of biomechanical signals is also increasingly recognised. In addition, cell...
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