Article
A two-amino-acid substitution in the transcription factor RORγt disrupts its function in TH17 differentiation but not in thymocyte development.
Nature immunology - 1 Oct 2017
He Zhiheng, Ma Jian, Wang Ruiqing, Zhang Jing, Huang Zhaofeng, Wang Fei, Sen Subha, Rothenberg Ellen V, Sun Zuoming
Abstract excerpt
The transcription factor RORγt regulates differentiation of the TH17 subset of helper T cells, thymic T cell development and lymph-node genesis. Although elimination of RORγt prevents TH17 cell-mediated experimental autoimmune encephalomyelitis (EAE), it also disrupts thymocyte development, which could lead to lethal thymic lymphoma. Here we identified a two-amino-acid substitution in RORγt (RORγtM) that...
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