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Single cell transcriptional diversity and intercellular crosstalk of human liver cancer

24 Mar 2022

Abstract excerpt

Liver cancer arises from the evolutionary selection of the dynamic tumor microenvironment (TME), in which the tumor cell generally becomes more heterogeneous; however, the mechanisms of TME-mediated transcriptional diversity of liver cancer remain unclear. Here, we assess transcriptional diversity in 15 liver cancer patients by single-cell transcriptome analysis and observe transcriptional diversity of tumor...

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PMID: 35322024
DOI: 10.1038/s41419-022-04689-w

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