Article
GWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include urate transporter genes.
Annals of the rheumatic diseases - 1 May 2017
Nakayama Akiyoshi, Nakaoka Hirofumi, Yamamoto Ken, Sakiyama Masayuki, Shaukat Amara, Toyoda Yu, Okada Yukinori, Kamatani Yoichiro, Nakamura Takahiro, Takada Tappei, Inoue Katsuhisa, Yasujima Tomoya, Yuasa Hiroaki, Shirahama Yuko, Nakashima Hiroshi, Shimizu Seiko, Higashino Toshihide, Kawamura Yusuke, Ogata Hiraku, Kawaguchi Makoto, Ohkawa Yasuyuki, Danjoh Inaho, Tokumasu Atsumi, Ooyama Keiko, Ito Toshimitsu, Kondo Takaaki, Wakai Kenji, Stiburkova Blanka, Pavelka Karel, Stamp Lisa K, Dalbeth Nicola, Sakurai Yutaka, Suzuki Hiroshi, Hosoyamada Makoto, Fujimori Shin, Yokoo Takashi, Hosoya Tatsuo, Inoue Ituro, Takahashi Atsushi, Kubo Michiaki, Ooyama Hiroshi, Shimizu Toru, Ichida Kimiyoshi, Shinomiya Nariyoshi, Merriman Tony R, Matsuo Hirotaka
Abstract excerpt
OBJECTIVE: A genome-wide association study (GWAS) of gout and its subtypes was performed to identify novel gout loci, including those that are subtype-specific. METHODS: Putative causal association signals from a GWAS of 945 clinically defined gout cases and 1213 controls from Japanese males were replicated with 1396 cases and 1268 controls using a custom chip of 1961 single nucleotide polymorphisms (SNPs). We...
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